Speakers

PLENARY SPEAKERS

Oliver Fiehn, University of California, Davis
Talk: Second-generation metabolomics: merging untargeted and targeted data acquisitions with MS-data independent analysis and virtual MS/MS libraries
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Prof. Oliver Fiehn has pioneered developments and applications in metabolomics with over 130 publications to date (http://scholar.google.com/citations?user=6BXzO88AAAAJ ), starting in 1998 as Postdoctoral scholar and from 2000 onwards as Group Leader (assistant professor) at the Max-Planck Institute for Molecular Plant Physiology in Potsdam, Germany. Since 2004 he is Professor at the UC Davis Genome Center, overseeing his research laboratory and the satellite core service laboratory in metabolomics research. Since 2012, he is Director of the NIH West Coast Metabolomics Center, supervising 35 staff operating 15 mass spectrometers and coordinating activities with 6 UC Davis satellite labs with a further 20 mass spectrometers and 5 NMR instruments. The West Coast Metabolomics Center provides the most extensive and most in-depth analysis of metabolites available today, using a range of validated protocols. Prof. Fiehn specifically aims at integrating new approaches or technologies, including pathway-based mapping and statistical and data processing tasks. The Center engages with users and collaborators in study designs. Prof. Fiehn specifically focuses on lipids and primary metabolism in cancer, cardiovascular diseases, diabetes and nutrition. He has chaired efforts in establishing metabolomic databases, libraries and standardizing metabolomic reports, including for the Metabolomics Society for which he served on the Board of Directors from 2005-2010 and 2012-2015, organizing a range of workshops and conferences.
Elaine Holmes, Imperial College, London
Talk: Systems Biology in Clinical Medicine
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Professor Holmes’ main research area focuses on applying metabolic profiling and computational modelling of biofluids and tissues to understand pathological and physiological processes. She has a broad background in metabolic chemistry, with specific expertise in spectroscopy and in chemometric modelling of spectral data.  She began her research career investigating molecular mechanisms of toxicology using spectroscopic methods and then broadened the scope to research clinical pathologies in a range of clinical fields.  Professor Holmes has several research projects investigating the consequences of modification of the gut microbiota and has particular interest in the gut-brain axis. This involves both the development and application of spectroscopic and chemometric methods, and in particular the fusion of metagenomic and metabonomic data to provide a readout of the functionality of the microbiome. In 2015, Professor Holmes was awarded the Interdisciplinary Prize Medal by the Royal Society of Chemistry. She holds Visiting Professorship, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, People’s Republic of China; William Glasser Visiting Professor, University of the Sciences, Philadelphia; CEU Madrid, Spain; Adjunct Professor, King Abdul Aziz University Saudi Arabia; Visiting Professor, Purdue University, West Lafayette Indiana, USA. Professor Holmes has an H-index of 83 and is an ISI Highly Cited Researcher (Pharmacology 2014). She has trained over 60 PhD students.
Stephen M. Rappaport, University of California, Berkeley
Talk: An untargeted adductomics pipeline for Cys34 of human serum albumin
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Over the last 30 years, my laboratory has developed and applied methods for measuring biomarkers of exposure in human populations and has used these measurements to investigate exposure-response relationships. Given my particular interest in small reactive molecules that initiate cancers and other chronic diseases, I have developed methods for detecting adducts of reactive electrophiles with blood proteins, especially human serum albumin (HSA), and have recently adapted these methods for untargeted analyses (adductomics). The adductomic studies began when I directed a NIEHS-funded center devoted to biological-response indicators (2007-2012) that brought together U.C. Berkeley scientists from Public Health, Chemistry, and Electrical Engineering. I have also been a prominent advocate of the exposome concept and organized two workshops on this topic for the National Academy of Sciences. With collaborating epidemiologists, I am now conducting Exposome-wide Association Studies (EWAS) that use untargeted methods to detect small molecules and adducts in biospecimens from diseased and healthy subjects with the goal of discovering disease causes. I have an active NIH grant (Project 2 of 1P01 ES018172) to develop and apply HSA-adductomics to extracts from dried blood spots collected at birth from childhood leukemia cases and controls, and have recently shown that the same samples (representing only 3 microliters of serum) can be used for untargeted analysis of thousands of small molecules. I am also a collaborator in the Exposomics Program funded by the EU to perform adductomic analyses with biospecimens from European cohorts. My laboratory has established in-house systems for tracking samples and data acquisition, with imbedded quality controls. Working with our collaborators, we also perform bioinformatics to investigate associations of detected features with case status and covariate effects.
David Sinton, University of Toronto
Talk: Microfluidic Analysis for Energy Applications
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David Sinton is a Professor and Associate Chair of Research in the Department of Mechanical and Industrial Engineering at the University of Toronto. Prior to joining the University of Toronto, Dr. Sinton was an Associate Professor and Canada Research Chair at the University of Victoria, Victoria, British Columbia, and a Visiting Associate Professor at Cornell University. Dr. Sinton’s research interests are in microfluidics and energy. This research involves the study and application of small scale fluid mechanics (microfluidics, nanofluidics, and optofluidics) to both advance renewable energy technologies and mitigate the impacts of current energy operations.  He became a Fellow of the Canadian Society for Mechanical Engineering in 2012, a Fellow of the American Society of Mechanical Engineers in 2013, and a Fellow of the Engineering Institute of Canada in 2015. He was the University of Toronto McLean Senior Fellow in 2013-2014, and became a member of the College of New Scholars within the Royal Society of Canada in 2015.
Jean-Louis Viovy, Institute Curie
Talk: Pushing Microfluidics towards Clinical Application
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Dr. Jean-Louis Viovy is research director at Institut Curie and CNRS, the French National Research Institute. He has a general training in liquid state and polymer chemical physics. He founded and heads the MMBM team. Dr Viovy received several awards, including the "Polymer Prize" of French Chemical Society, 1996, the "Philip Morris Prize for Science", speciality Biophysics, 1997 and the 2004 and 2005 French Ministery of Research Awards for Innovative Technology Company Creation, and ERCadg in 2013. Jean-Louis is a member of the board of several international journals, and of the international Chemical and Biological Microsystems Society. He was chairman of MicroTAS 2007, and he is cofounder of Institut Pierre Gilles de Gennes for Microfluidics (IPGG), a new Institute dedicated to state-of-the-art microfluidics research in Paris.

INVITED SPEAKERS

Advanced Column Technologies

Wim De Malsche
Vrije Universiteit Brussel
Title: Achieving high efficiencies and peak capacities using pillar array columns

Biologics/Glycan Analysis

Christian Neusüß
Aalen University, Germany
Title: Glycan and intact protein analysis: from CE-MS to CE-CE-MS

CE-MS/Novel Detection Strategies

Norman Dovichi
Notre Dame University
Title: Capillary Zone Electrophoresis for Deep Bottom-up Proteomic Analysis

Clinical Diagnostics & POC Devices

Jonathan Posner
University of Washington
Title: Highly Sensitive Point of Care Immunoassays Using Electrokinetics on Paper

Comprehensive “-OMICS”

Alexander Ivanov
Northeastern University
Title: Enabling deep Proteomic Profiling of Small Populations of Rare Cells Isolated from Whole Blood and other Tissue Samples
Liang Li
University of Alberta
Title: High-Performance Chemical Isotope Labeling LC-MS for Comprehensive and Quantitative Metabolomics

Environmental Analysis

Frank Dorman
Penn State University
Title: Why is Firefighting Dangerous?: Characterization of Mixed-Halogen and Furans in Fire Debris using GCXGC-TOFMS and APGC-MS/MS

Food, Nutrition & Health

David Wishart
University of Alberta
Title: New Resources for Enabling Food and Nutritional Metabolomics
Peter Zahradka
St. Boniface Hospital
Canadian Centre for Agri-food Research
in Health and Medicine
Title: Application of Bioanalytical Methods to Foods for the Optimization of Health and Nutritional Benefits

Fundamentals & Biointeractions

Gert Desmet
Vrije Universiteit Brussel
Title: What Causes the High Efficiency and Speed of Core-shell Particles and How Can Micro-scale Separations Benefit From This Knowledge

Future Stars in Microseparations

Deirdre Cabooter
Leuven University
Title: Detailed Evaluation of Mass Transfer Phenomena in Hydrophilic Interaction and Reversed-Phase Liquid Chromatography under Identical Packing Conditions
Jesse Greener
Laval University
Title: Laminar flow separation of bacterial biofilms coupled with optical and chemical visualization for analysis of bio-catalytic products
Takayuki Kawai
Riken Quantitative Biology Centre
Title: High performance CE-MS system for single cell analysis
Rawi Ramautar
Leiden University
Title: Two birds with one stone: a single CE-MS approach for anionic and cationic metabolic profiling

Ion Mobility Spectrometry

Stephen J. Valentine
West Virginia University
Title: Developing IMS and HDX Techniques/Models for Characterizing Protein Complex Structure
Brandon T. Ruotolo
University of Michigan
Title: Collision Induced Unfolding: A New Paradigm in Protein Stability Measurements

Microfluidics/Lab-on-a-Chip

D. Jed Harrison
University of Alberta
Title: High Efficiency Molecular Sieving of Biomolecules in Self Assembled Nonporous Media
Jean-Louis Viovy
Institut Curie
Title: Using Microfabrication to build Complex and Functional Cell Arrays

Multidimensional Separation

Frederic Lynen
University of Ghent
Title: Microscale Analysis of Therapeutic Oligonucleotides via Comprehensive Liquid Chromatography and Capillary Electrophoresis

Nucleic Acids & Biosensors

Igor Lednev
University at Albany - SUNY
Title: Raman Microspectroscopy and Advanced Statistics for Forensic Applications and Medical Diagnostics
Leyla Soleymani
McMaster University
Title: Developing fully-integrated biosensing systems on the laboratory benchtop

Pharmaceutical & Chiral Analysis

Janusz Pawliszyn
University of Waterloo
Title: SPME in Bioanalysis: where does it fit?

Sample Preparation

Fred Regnier
Purdue University
Title: Accelerating The Sample Preparation Component